Catalytic Active Site Prediction (CLASP)

CLASP uses structural and electrostatic properties in a protein to predict its function. A motif from the protein of known function and 3D structure provides the initial template for searching spatially congruent matches (example motif ). These matches are then pruned by the observation that the potential difference (calculated using APBS) in pairs of residues in active sites are highly correlated. Our method can interrogate any given hypothetical protein with known structure for various motifs ( either derived from the CSA database or added by us) and rank the matches. This further allows CLASP in classifying promiscuous and moonlighting activities associated with the protein.

Some of the most promiscuous proteins as predicted by CLASP