Basic interface and QC for genotypes from Illumina Infinium arrays


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Documentation for package ‘argyle’ version 0.1

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A B C D E F G H I K L M N O P Q R S T V W X Y misc

argyle-package argyle: An 'R' package for import and QC of genotypes from Illumina Infinium arrays

-- A --

apply.filters Drop samples and/or markers flagged as low-quality
argyle argyle: An 'R' package for import and QC of genotypes from Illumina Infinium arrays
as.genotypes.cross Convert an 'R/qtl' object to a 'genotypes' object
as.rqtl.genotypes Convert a 'genotypes' object to an 'R/qtl' object
assoc.plink Perform a genome-wide association scan with PLINK
autosomes Shortcut for grabbing just the autosomes

-- B --

bafplot Plot B-allele frequency (BAF) and log2-intensity ratio (LRR) for a sample
blank.grob Make a blank grob for plotting

-- C --

cbind.genotypes Concatenate two 'genotypes' objects 'horizontally'
consensus Identify the consensus genotype call among a group of samples

-- D --

dist Calculate a simple genetic distance: proportion of alleles shared IBS
dist.genotypes Calculate a simple genetic distance: proportion of alleles shared IBS
dotplot Show a visual representation of a slice of a genotype matrix
dotplot.genotypes Show a visual representation of a slice of a genotype matrix
drop.intensity Strip intensity matrices from a 'genotypes' object

-- E --

ex Genotype calls and intensities from the GigaMUGA array for mouse
export.doqtl Export genotyping result in format suitable for DOQTL

-- F --

filter.plink Filter markers and samples from a dataset with PLINK
filters Get filters attached to a 'genotypes' object
filters.genotypes Get filters attached to a 'genotypes' object
fixed.diffs Identify fixed differences between a pair of samples
freq Calculate allele frequencies by marker or sample
freqplot Plot frequencies of missing, heterozygous, and minor-allele calls across genome

-- G --

genoapply Apply a function over a 'genotypes' object, by sample or marker groups
genotypes Constructor for a 'genotypes' object
get.baf Extract BAF/LRR as a dataframe
get.call Extract genotype calls as a dataframe
get.intensity Extract hybridization intensities as a dataframe
ggmanhattan Create skeleton of a 'Manhattan plot' (concatenated chromosomes) with 'ggplot2'
guess.parents Attempt to guess the mother-father pair corresponding to offspring

-- H --

has.intensity Check if a 'genotypes' object has intensity data attached
head.genotypes Show the first few samples and markers for a 'genotypes'
heatmap Plot a heatmap representing genetic distances between samples
heatmap.genotypes Plot a heatmap representing genetic distances between samples
heterozygosity Calculate heterozygosity by marker

-- I --

informative Find markers informative between sample groups
intensity Get intensity matrices attached to a 'genotypes' object
intensity.genotypes Get intensity matrices attached to a 'genotypes' object
intensity.vs.ref KS-test for difference in intensity distributions
intensityhist Plot histogram of (sum-)intensities by sample
is.filtered Check if markers or samples are marked with filters

-- K --

kinship.plink Compute realized kinship matrix (aka GRM) with PLINK

-- L --

ld.plink Compute pairwise LD between markers with PLINK

-- M --

maf Calculate minor-allele frequency (MAFs) from a genotypes matrix
markers Get marker map for a 'genotypes' object
markers.genotypes Get marker map for a 'genotypes' object
mds.plink Perform classical multidimensional scaling (MDS) with PLINK
mendel.distance Compute rate of Mendelian inconsistency between an individual and possible mother-father pairs.
merge.genotypes Merge two 'genotypes' objects which share markers
missingness Calculate rate of missing genoypes by marker or sample

-- N --

nmiss Count number of missing genotypes by marker or sample

-- O --

oneway Get one-way marker-phenotype association
oneway.plot Make graphical representation of a 'one-way' genotype-phenotype contingency table

-- P --

pca Perform PCA on genotypes with PLINK
pca.genotypes Perform PCA on a 'genotypes' object
pca.plink Perform PCA on genotypes with PLINK
plinkify Create a pointer to a PLINK fileset
plot.clusters Plot 2D hybridization intensities at a few markers
plot.haplotypes Plot the results of haplotype reconstruction
plot.pca.result Auto-plotting of a PCA result
predict.f1 Predict genotype of an F1 individual given genotypes of its parents
predict.sex Predict sample sexes based on genotype and intensity data
prop.het Calculate the proportion of sites at which each sample is heterozygous
prune.plink Prune markers by pairwise LD with PLINK

-- Q --

qcplot Produce a visual summary of QC measures
quantile.normalize Perform quantile normalization of intensity data.

-- R --

rbind.genotypes Concatenate two 'genotypes' objects 'vertically'
read.beadstudio Read genotype calls and hybridization from Illumina BeadStudio output.
read.plink Read a PLINK binary fileset into a 'genotypes' object
recode Switch between character and numeric representations of genotype calls
recode.genotypes Switch between character and numeric representations of genotype calls
recode.to.parent Recode genotypes against genotypes of a parent
reconstruct.haps Perform (simplistic) haplotype reconstruction, given parental genotypes
replace.map Swap out the marker map for a different one
replace.names Rename some or all samples
run.marker.qc Perform basic marker-wise QC on genotype calls
run.sample.qc Perform basic sample-wise QC on genotype calls and intensities

-- S --

samples Get sample metadata for a 'genotypes' object
samples.genotypes Get sample metadata for a 'genotypes' object
scale_fill_heatmap A red-to-orange color scale for heatmaps
scale_x_genome Custom x-axis scale for genome coordinates.
scale_y_logp Custom y-axis scale for -log10(p-values)
segregating Identify segregating sites among a group of samples
sex.genotypes Extract vector of sample sexes
sextable Print summary table of sample sexes
subset.genotypes Subset a 'genotypes' object by markers or samples
summarize.calls Summarize genotype calls by sample or marker
summarize.filters Show tally of filters failed by sites, samples.
summarize.intensity Summarize hybridization intensity by sample

-- T --

tdt.plink Perform family-based transmission diseqiulibrium test (TDT) with PLINK
theme_axesonly A graphics theme with only an x-axis
theme_gbrowse A genome-browser like graphics theme
theme_heatmap A graphics theme suitable for heatmaps
theme_nothing A very minimal graphics theme
tQN Perform tQN normalization of intensity data.
twoway Get two-way (marker x marker)-phenotype association
twoway.plot Make graphical representation of a 'one-way' genotype-phenotype contingency table

-- V --

validate Check the integrity of a 'genotypes' object
validate.genotypes Check the integrity of a 'genotypes' object

-- W --

weir.fst Compute Weir & Cockerham's F_st estimator using PLINK
weir.fst.plink Compute Weir & Cockerham's F_st estimator using PLINK
write.hgdp Export genotypes in Stanford HGDP format
write.plink Write a 'genotypes' object as a PLINK binary fileset

-- X --

xchrom Shortcut for grabbing just chrX

-- Y --

ychrom Shortcut for grabbing just chrY

-- misc --

$.genotypes Access attributes of a 'genotypes' object as if they were a list
[.genotypes Indexing into a 'genotypes' object